单纯性脂肪肝与血清瘦素水平关系的初步探讨

Relationship between Serum Leptin and Fatty Liver

目的 探讨脂肪肝与血清瘦素水平的关系。方法 选择单纯性脂肪肝患者 2 3例 ,正常对照者 1 7例 ,分别测定受试者的血清瘦素水平 ,以及肝功、血脂、血糖等指标。测量受试者的身高、体重 ,计算体重指数 (BMI)、体脂肪含量 (%Fat)。瘦素采用酶联免疫 (ELSA)方法测定。结果 脂肪肝组血清瘦素水平平均高于对照组 (P <0 .0 5) ,进行相关分析发现血清瘦素与BMI、%Fat、丙氨酸氨基转移酶 (ALT)、胆碱脂酶 (CHE)相关。结论 脂肪肝患者血清瘦素水平是升高的 ,且与其发生、发展有关。

Objective To determine the Relationship between serum leptin and fatty liver. Methods 23 patients with fatty liver, and 17 normal persons were admitted to the investigations.The blood glucosi, liver function, blood leptin from serum and partial ascites, the candidates height and weight were measured respectively, simultaneously, body mass index and percent body fat was calculated. The level of leptin was measured by ELISA. Results The serum leptin level from the test group was compared with that from the control group(p<0.05). The level of leptin in fatty liver rose obviously than that of the controls. The serum leptin in fatty liver is relevant to BMI, %fat, ALT , CHE. Conclusions The serum leptin in fatty liver is abnormal and correlates with the disease itself.