膀胱移行细胞癌中p53、mdm2蛋白表达和意义

Expression of P53 and Mdm2 Proteins in Transitional Cell Carcinoma of Urinary Bladder and Implication.

目的 :探讨P53、mdm2蛋白表达与膀胱移行细胞癌 (TCC)生物学行为的关系。 方法 :用免疫组织化学S -P法检测 59例膀胱TCC组织中P53、mdm2蛋白的表达。结果 :膀胱TCC组织中P53蛋白阳性表达率为 54 .2 % ,低分化、浸润性癌组织中P53蛋白阳性表达明显高于高分化、浅表性癌组织 (P <0 .0 5) ,mdm2蛋白阳性表达率为 47.5 % ,高分化、浅表性癌组织中mdm2蛋白阳性表达明显高于低分化、浸润性癌组织 (P <0 .0 0 5)。P53和mdm2蛋白表达呈负相关 (P <0 .0 5) ,P53蛋白阳性表达组 3年成活率低 ,复发率高 (P <0 .0 5)。结论

Objective To explore the correlation between the expression of p53 and mdm2 proteins and the transitional cell(TCC) of urinary bladder.Methods Immunohistochemical method was used to detect the p53 and mdm2 proteins expression in 59 cases with the TCC of urinary bladder.Results The positive rate of p53 prtein expression in the TCC of urinary bladder was 54.2%,The positive expression of P53 protein in poorer dfferentiational and advanced tumor was more than the higher differentiational and superficial tumor(p<0.05),The positive rate of mdm2 protein expression was 47.5%,The positive expression of mdm2 protein in higher differentiational and superficical tumor was more than in poorer differentiational and advanced tumor(P<0.05).The expressions of p53 protein and mdm2 protein were reversely correlated (P<0.05). Recurrence rate in positive group of P53 was higher than in negative group(P<0.05),3 year survival in positive group of P53 was less than in negtive group(P<0.05).Conclusion the abnormal expressions of P53 and mdm2 proteins play an important role on the occurrence and progress of the TCC of urinary bladder.