米索前列醇与催产素预防产后出血效果的随机对照研究

Evaluation of misoprostol and syntocinon in prevention of postpartum hemorrhage using completely ramdom design

目的 :观察米索前列醇与催产素预防产后出血的疗效比较。方法 :31 8例产妇随机分为两组 ,米索前列醇组 (米索组 ) 1 62例 ,在胎头着冠后立刻给予口服米索 60 0 μg,催产素组 1 56例 ,在胎儿前肩娩出后立刻给予子宫体部注射催产素 2 0 IU。结果 :米索组第三产程时间明显短于催产素组〔(7.2± 3.9) min vs (9.9± 3.9) min〕;产后 2 h出血量明显少于催产素组〔(1 60 .4± 73.4) m L vs (2 4 0 .3± 1 0 3.4)m L〕,差异均有显著性 (P<0 .0 5)。结论

Objective:To compare the efficacy of misoprostol and syntocinon in preventing postpartum hemorrhage Methods:Three hundreds and eighteen gravidae were randomly divided into misoprostol group( n =162)and syntocinon group( n =156) The former group took oral administration of 600μg misoprostol at the crowning of head, while the latter one received intramuscularly injection of 20IU syntocinon in uterine body at the expulsion of the former shoulder Results:The third stage of labor and the amount of bleeding at 2 hrs postpartally in misoprostol group were much less than those in syntocinon group [(7 2±3 9)min vs (9 9±3 9)min, P< 0 05;(160 4±73 44)mL vs (240 3±103 4)mL, P <0 01] Conclusion:The efficacy of misoprostol in preventing postpartum hemorrhage could be superior to that of syntocinon