创伤性休克患者血清血管内皮生长因子的变化及其意义

Change of serum level of vascular endothelial growth factor in patients with traumatic shock and its significance

目的 :探讨血管内皮生长因子 (VEGF)在创伤性休克发生机制中的作用。方法 :采用酶联免疫吸附 (ELISA)法 ,测定创伤性休克患者 43例 (创伤休克组 )、创伤非休克者 40例 (创伤非休克组 )及正常对照 30例 (对照组 )血清中 VEGF的水平。结果 :(1 )与正常组的(1 2 .32± 4.1 8) ng/ L相比 ,创伤非休克组及创伤性休克组 VEGF水平明显上升 ,分别为 (67.35± 2 5.2 2 ) ng/ L、(1 53.41± 2 8.1 8) ng/ L,差异均有极显著性 (P<0 .0 1 )。(2 )创伤性休克组 VEGF水平明显高于创伤非休克组 (P<0 .0 1 )。(3)随创伤休克的病情加重 ,VEGF水平呈逐渐升高趋势 (P<0 .0 1 )。结论 :创伤后 VEGF水平明显升高可能是创伤性休克发病机制中的一个重要因素。

Objective:To investigate the role of serum vascular endothelial growth factor (VEGF)in the pathogenesis of traumatic shock Methods:Serum levels of VEGF were detected with ELISA in 30 heal thy persons,40 traumatic patients without shock and 43 patients with traumatic shock Results:Serum concentration of VEGF in shock group was significantly higher than that in non shock group(153 41±28 18 vs 67 35±25 22, P <0 01),and serum levels of VEGF in both traumatic groups increased remarkably in comparison with control group( P <0 01) There was a trend that serum level of VEGF in shock group enlarged markedly with the shock severity Conclusion:The increase of serum level of VEGF might play an important role in the pathogenesis of traumatic shock