骨矿含量测定在婴儿佝偻病的早期诊断价值

Bone Mineral Content Measurement in Diagnosis of Early Infant Rickets.

【目的】 探讨骨矿含量测定在昆明地区婴儿佝偻病早期的诊断价值。 【方法】 对本地佝偻病活动期婴儿 3 1例及正常婴儿 3 3例采用单光子吸收法 (SPA)测定其骨宽 (BW ) ,骨矿含量 (BMC)和骨密度 (BMD) ,用微量条形酶免疫测定法测定上述两组的骨碱性磷酸酶 (BALP) ,并做X线手腕片检查 ,将各项结果进行统计学处理。 【结果】 与正常婴儿组相比 ,佝偻病组BMC明显降低 ,BALP明显升高 ,差异显著 (P <0 .0 5 )。在佝偻病组BMC阳性率为 87% ,手腕X线阳性率为 19% ,两组比较差异显著 (P <0 .0 5 ) ;而与BALP阳性率 90 %相比 ,则差异不明显 (P>0 .0 5 ) ,并且BMC与BALP呈中度负相关 ,相关系数为 0 .42。 【结论】 认为SPA检测技术对本地区婴儿佝偻病早期诊断具有特异性。

To study evaluation of the diagnosis with bone mineral content measurement for early infant rickets in Kunming region. In infants with early rickets(31 experiment group), and normal infants 33 as control group, the width of bone (BW), bone mineral content (BMC) and bone mineral density (BMD) by single photon absorptiometry(SPA), bone alkaline phosphatase(BALP) of serum, and X ray film of left wrist by radiography were measured. The datum were analyzed with SPSS according to the tables had been designed. The infant BMC levels in experimental group were significantly lower than control group(P<0.05),BALP levels were significantly higher than control group(P<0.05). In the experimental group, BMC lever correlated with BALP lever significantly, correlative coefficient was 0.42; the abnormal rates in BMC and, left wrist X ray film were 87% and 19%, which had significant difference between two rates; but the abnormal rates of BALP and BMC were 90% and 87%, which had no differences.[Conclusions] Singlephoton absorptiometry is sensitive technique for early clinical diagnosis of infant rickets. It has specific value.