胎膜早破孕产妇脐血中IL-6、IL-8含量与新生儿预后关系的研究

The Relationship Between Concentration of Interleukin-6、Interleukin-8 in Omphaloblood of Newborn for Pregnancy Women With Premature Rupture of Membrane(PROM) and Prognosis of Fetal.

【目的】 探讨胎膜早破孕产妇的新生儿脐血中IL 6、IL 8的含量及新生儿预后的关系。 【方法】 用ELISA方法检测了 5 0例胎膜早破孕产妇的新生儿及 5 0例正常足月孕产妇的新生儿脐血中IL 6、IL 8的含量 ,并进行对照分析。羊膜腔感染以后病理诊断确诊。 【结果】 胎膜早破孕产妇新生儿脐血中IL 6、IL 8的含量明显高于正常足月孕产妇的新生儿 ,且随破膜时间延长 ,其含量逐渐增高。并发羊膜腔感染病人的新生儿脐血中IL 6、IL 8的含量显著高于Apgar评分≥ 8分新生儿的母亲。 【结论】 新生儿脐血中IL 6、IL 8的含量在预测羊膜腔感染及新生儿预后有重要意义。

To determine the relationship between omphaloblood IL 6,IL 8 concentrations(OIC) of newborn for pregnancy women with PROM group(PG) and prognosis of fetal. OIC were examined in 50 newborns of PG and 50 normal newborns of control group(CG) by ELISA. The OIC of PG were significant higher than CG, and the OIC of PG also increased with prolonged time of PROM. The pregnant women suffered intraamnion infection (IAI) and their IL 6?IL 8 concentrations significantly higher than that without IAI. The neonates whose Apgar score≤7' and their OIC were significantly higher than the neonates whose Apgar score≥8'.[Conclusions] The OIC of pregnancy women with PROM would help to predict IAI and estimate fetus prognosis.