慢性肾小球疾病血清纤维化指标临床研究

Clinical Research on Serum Fibrosis Index of Chronic Glomerular Disease

目的 :探讨原发性肾小球疾病肾内纤维化病变情况。方法 :用放免法对 1 63例原发性肾小球疾病血清 型胶原 ( C- )、层粘蛋白 ( LN)及 型前胶原 ( PC- )等纤维化指标进行测定 ,同时用发色底物法测定血浆纤溶酶原激活物 ( t PA)及 t PA抑制物 ( PAI- 1 )。结果 :各型肾小球疾病与健康人比较 ,血清 C- 、LN、及 PC- 均显著增高 ( P<0 .0 1 ) ,血浆 t PA降低 ( P<0 .0 1 )及 PAI- 1增高 ( P<0 .0 1 )。肾功能衰竭期 PC- 及 PAI- 1比肾功能正常期更高 ( P<0 .0 1 ,P<0 .0 5 )。结论 :原发性慢性肾小球疾病肾内均存在纤维化改变 ,肾功能衰竭期更为明显 ,为慢性肾小球疾病抗纤维化治疗提供了依据。

Objective: To study the fibrosis condition ins45ide kidney of original developed glomerular disease.Methods:The serum fibrosis indexes of 163 cases of original developed glomerular disease,such as C Ⅳ, LN and PC Ⅲ, were checked by radioimmunol methods. The levels of plasma tPA and PAI 1 were examined by luminous bottom methods. Results: Compared the all kinds of glomerular disease and normal group, the levels of serum C Ⅳ, LN, PC Ⅲ and plasma PAI 1in former were obvious increased( P <0.01),while the level of plasma tPA in former was decreased( P <0.01). The levels of PC Ⅲ and PAI 1 in kidney function exhausted period were obviously higher than those in kidney function normal period( P <0.01, P <0.05).Conclusion:There are fibrosis in all kinds of original developed chronic glomerular disease, esp. obvious in kidney function exhausted period,which provides basis of anti fibrosis treatment on chronic glomerular diseases.