棒状杆菌ps1产生广谱抗真菌活性物质的初步研究

An Antifungal Compound Produced by Corynebacterium spp .

棒状杆菌ps1能产生广谱抗真菌活性物质 ,对其活性物质的抗菌谱、产生条件和部分特性进行了初步研究。棒状杆菌ps1产生的活性物质psch1对白色念珠菌、丝核菌、镰刀菌等多种真菌均有强烈抑制作用 ,并具有良好选择性。活性物质psch1耐热性好 ,pH改变对其活性影响较明显 ,酸性环境有利于其稳定但在碱性条件下容易失活。

A bacterium which produced antifungal compound from cultured broth was isolated from the intestinal tract of an insect. The organism was initially ide ntified as Corynebacterium spp. The compound has broad spectrum of antifunga l activities. It is effective against Candida albican, Verticillum alboatrum, Fusarium spp., Rhodotorula rubra, Aspergillus niger, Aspergillus flavus, Rhi zopus nigricans, Aspergillus ficuum, Rhixoctonia solaai and Trichoderma viri de. It is stable at high temperature. After treatment at 121 ℃ for 30 min onl y 35% of the total activity is lost. However, pH has profound effect on the acti vity. It is stable in acidic conditions and unstable in alkaline conditions.