纳米羟基磷灰石修复牙槽骨缺损的动物实验研究

Animal experimental study on alveolar bone defect with Nano-hydroxyapatite

目的 :探讨纳米羟基磷灰石 (Nano- HA)的生物学性质和在牙槽骨缺损修复中的成骨机制 ,为进一步的动物和临床实验提供理论依据。方法 :在兔牙槽骨颊侧骨板做人为骨开窗 ,实验组填入纳米羟基磷灰石 ,空白对照组不做充填 ,羟基磷灰石对照组充填普通羟基磷灰石 (HA)。于 4周、8周、12周分别处死动物做组织学切片。结果 :实验组无异物排斥反应 ,Nano-HA参与骨形成最终被降解 ,骨修复显著 ,大量新骨形成 ,与空白对照组的骨修复比较快速而且活跃。结论 :Nano- HA具有良好的生物相容性、生物降解性、骨引导性 ,能加速牙槽骨的修复 ,为应用 Nano- HA修复牙周病引起的牙槽骨缺损提供了理论依据。

Objective: To observe the reconstruction of alveolar bone defect by using Nano-hydroxyapatite(Nano-HA) and to provide theoretical basis for further animal and clinical study. Methods: Nano-HA was implanted in man-made alveolar bone defect in experimental group, with nonimplanted or implanted hydroxyapatite(HA) as control group .Make observation was made by using histological study at 4,8,12 weeks. Results: Histological study showed Nano-HA participated in new bone formation, was hardly rejected by hosts and was degraded at last. with new more bone formation in experiment group than in control group. Conclusions: Nano-HA has better biocompatibility, biodegradation and osteoconductivity.It may accelerate alveolar bone reconstruction.