摘要
[目的]检测直肠癌组织中与浸润转移过程相关的蛋白钙粘素(E-cad)、基质金属蛋白酶-9(MMP-9)、血管内皮细胞生长因子(VEGF)的表达,探讨这些因素与大肠癌浸润、转移的相关性,以期寻找能够进一步判断大肠癌浸润转移潜能的分子生物学指标。[方法]采用免疫组化SP方法检测90例直肠癌中E鄄cad、MMP-9、VEGF的表达。[结果]E-cad的表达随着癌组织的分化程度的降低而降低,随浸润深度的加深及转移的出现逐渐下调。MMP鄄9的表达随着浸润深度的加深及淋巴结转移的出现而逐渐增强。VEGF的表达与淋巴结转移呈正相关。[结论]直肠癌的浸润和转移与E-cad、MMP-9、VEGF的表达具有显著相关性。应用多种抗体检测肿瘤相关蛋白并分析其表达的意义,将有助于判断直肠癌的浸润、转移潜能及预后,为临床治疗方案的选择提供理论依据。
To investigate the relationship between expression of E-cadherin(E-cad),matrix met-alloproteinases-9(MMP-9),vascular endothelial growth factor(VEGF)and invasion,metastasis of rectal cancer.The streptavidin-peroxidase immunohistochemistry was taken in90cases of rectal cancer.The expression of E-cad was reduced with the lowing of differentiation degree,the increase of the depth of invasion and lymph node metastasis.The expression of MMP-9was enhanced with the increase of the depth of invasion and lymph node metastasis.The expression of VEGF was correlated with the lymph node metastasis.[Conclusion]The positive expression of E-cad,MMP-9and VEGF in rectal cancer tissue was cor-related with the invasion and metastasis of rectal cancer.The expression may be important to the determina-tion of the malignant biological property and the prognosis of rectal cancer.
出处
《肿瘤学杂志》
CAS
2003年第3期138-140,共3页
Journal of Chinese Oncology
关键词
直肠肿瘤
浸润
转移
钙粘素
基质金属蛋白酶—9
血管内皮细胞生长因子
rectal neoplasms
invasion metastasis
E-cadherin
matrix metalloproteinases-9
vascular endothelial growth factor
