食管癌微血管密度与临床病理特征

The Relationship Between Microvessel Density and Clinicopathological Characteristics in Esophageal Carcinoma

［目的］观察食管鳞状细胞癌组织中微血管密度(microvessel density,MVD),分析其与临床病理特征的关系和临床意义。［方法］采用免疫组织化学法(immunohistochemistry,IHC),检测６２例食管癌组织中微血管密度，并结合临床病理特征进行统计学分析。［结果］肿瘤组织２００倍视野内微血管计数平均值为５６．３２±１５．４１。肿瘤大小在２cm～５cm和≥５cm两组的MVD与≤２cm组相比，其差异分别具有显著性和非常显著性(P＜０．０５和P＜０．０１);淋巴结转移＞３个者MVD显著高于淋巴结阴性者（P＜０．０１);复发转移者MVD显著高于无病生存者(P＜０．０１);MVD在不同肿瘤部位和组织学分级中未见明显差异(P＞０．０５)。［结论］MVD与肿瘤的大小、淋巴结转移数目、复发转移密切相关，可能成为食管癌一个预后因素。

To investigate the relationship between microvessel density(MVD)and clinicopathological characteristics,and its clinical significance in patients with esophageal squamous cell carcinoma.MVD in tumor tissues was measured by immunohistochemistry in62cases with esophageal carcinoma.Correlations between MVD and clinicopathological characteristics were analyzed.The mean of MVD was56.32±15.41in tumor tissuses.MVD in tumor size2cm～5cm(55.81±13.96)and≥5cm(66.26±17.18)were significantly higher than that in tumor size≤2cm(43.48±16.31),P<0.05and P<0.01;MVD in lymph node positive(>3)group(64.50±16.11)was significantly higher than that in lymph node negative group(47.51±14.22).MVD in relapsed or metastatic group(60.44±13.22)was significantly higher than that in disease free group(45.81±16.16)(P<0.01);Whereas no correlation was found between MVD and tumor location,histologic grade(P>0.05).[Conclusion]MVD was related with tumor size,number of positive lymph node,relapsed or metastatic status.It could be an independent prognostic factor in esophageal carcinoma.