糖尿病大鼠海绵体神经诱发电位的实验研究

Experimental Study of Corpus Cavernosal Nerve Evoked Potential in Diabetic Rats

目的 :观察糖尿病 (DM)性大鼠海绵体的神经病变。 方法 :3 5只SD大鼠随机分为造模组 ( 2 5只 )和空白对照组 ( 10只 )。造模组应用腹腔内单次注射链脲佐菌素 ( 63mg/kg)制造DM模型。单波刺激海绵体神经 ,测定反射潜伏期及肌电位。 结果 :海绵体神经 海绵体平滑肌传导潜伏期中 ,DM组所需时间明显长于其他各组 (P <0 .0 1)。同时 ,与其他各组相比 ,其海绵体平滑肌电位明显升高 (P <0 .0 1)。 结论

Objectives: To observe the cavernosal nerve dysfunction of diabetic Sprague Dawley rats. Methods: Thirty-five Sprague-Dawley rats were divided randomly into diabetes model group(n=25) and normal group(n=10). Diabetes model was established by administration of streptozotocin (63 mg/kg) in single intraperitoneal dosing. Giving single wave stimulus, corpus cavernosal nerve was measured for its latent period of reaction and myopotential. Results: Compared with other groups, diabetic rats had longer reflection latent period(P< 0.01) and higher corpus cavernosum smooth muscle myopotential (P< 0.01). Conclusions: The results indicate that corpus cavernosal nerve dysfunction may play an important role in the erectile dysfunction of diabetic rats. Natl J Androl,2003,9(3):181-183