摘要
本文研究血管外膜在血管重塑及功能调控中的作用。实验采用在体去除兔颈动脉外膜的方法 ,于术后即刻、1周及 2周取出动脉作组织学、免疫组织化学染色及血管反应性测定。结果显示 :( 1)去除颈动脉局部外膜对内皮及中层平滑肌无明显损伤 ;( 2 )去除外膜后血管平滑肌细胞增殖 ,并有新生内膜形成 ;( 3 )与对照侧比较 ,去外膜侧血管对去甲肾上腺素的收缩反应在术后即刻及 1周时减弱 (P <0 0 5 )。上述研究结果提示 :去除动脉外膜可导致血管内膜增殖及血管平滑肌收缩功能的改变 。
The aim of the present study was to investigate the effect of removal of the adventitia on vascular remodeling and vasoconstriction of the carotid artery in New Zealand rabbit. Adventitia of carotid artery was removed mechanically. The histology, morphology and reactivity of the carotid artery was observed by immunohistochemistry and measurement of carotid ring tension immediately, 1 week and 2 weeks after removal of the adventitia. No damage of intima and media was observed after removing the adventitia. Removal of the adventitia caused a remarkable proliferation of the vascular media and formed the neointima. Compared with the control ring, norepinephrine (NE)-induced vasocontraction in adventitia -denuded carotid artery was significantly reduced immediately and 1 week after the operation (P<0.05). Adventitia removal promoted the neointima formation and decreased vasoconstriction of the carotid artery, indicating that the adventitia is involved in the regulation of vascular remodeling and vasoconstriction.
出处
《生理学报》
CAS
CSCD
北大核心
2003年第3期290-295,共6页
Acta Physiologica Sinica
