血塞通注射液对慢性肺心病急性加重期肺动脉高压、血液高凝状态的影响

Clinical Study on Effect of Xuesaitong Injection on Pulmonary Artery Pressure and Coagulation in patients with Cor Pulmonale during Acute Attack

目的 观察血塞通注射液对慢性肺心病急性加重期患者相关理化指标的影响,并探讨其作用机制。方法 将慢性肺心病急性加重期患者随机分为治疗组和对照组。两组均予西医常规治疗,治疗组加用血塞通注射液,对照组加用低分子肝素钙。测定两组治疗前后平均肺动脉压(mPAP)、血浆内皮素-1(EF-1)、纤维蛋白原(Fg)及D-二聚体(D-D)水平。结果 治疗组给药后mPAP ET-1、Fg、D-D均较治疗前显著改善,且mPAP、ET-1改善情况优于对照组。结论 血塞通注射液能明显降低肺动脉高压,其机制可能是保护血管内皮细胞,减少或桔抗缩血管活性物质,抗凝及促进血栓溶解。

Objective: To investigate the therapeutic effect and possible mechanism of Xuesaitong Injection on cor pulnionale during acute attack. Methods: 69 patients with pulmonale during acute attack were divided randomly into two groups, the treatment group (n = 35) and the controlled group ( n = 30). Besides routine treatment of WM, patients in treatment group was administrated with Xuesaitong Injection, while those in controlled group received Nadroparin Calcium Injection. Before and after treamet, levels of mean pulmonary artery pressure (mPAP), plasma endothelin (ET) - 1, fibrinogen(Fg) and D -dirner(D-D) were measured. Results: In the treatment group, levels of mPAP, plasma ET - 1, Fg, D-D were singificantly lower than those before treatment, and levels of mPAP. ET - 1 were also significantly lower than those in controlled group. Conclusion: Xuesaitong Injection can significantly reduce pulmonary artery pressure and the possible mechanism may be related to the protection of vascular endothelial cells, decreasing or antagonizing vasoconstrictor factors anticoagulating and promoting the lysis of thrombus.