慢性阻塞性肺病病人α-颗粒膜蛋白及D-二聚体的变化

THE CHANGES IN THE CONCENTRATIONS OF α-GRANULAR MEMBRANE PROTEIN AND D-DOUBLE DIME

目的 探讨血小板活化、凝血激活与慢性阻塞性肺病 (COPD)的关系及其临床意义。方法 用酶联免疫双抗体夹心法分别测定 30例COPD患者急性期和缓解期血浆α 颗粒膜蛋白(CD62P)、D 二聚体浓度 ,并与 2 2例健康者血浆CD62P、D 二聚体测定结果作对照。结果 COPD患者急性期血浆CD62P、D 二聚体浓度显著高于对照组 (P <0 .0 1)。缓解期血浆CD62P、D 二聚体浓度有所下降 ,但仍高于对照组 (P <0 .0 5 )。结论 血小板活化。

Objective To explore the correlation between the platelet and coagulation activations and chronic obstructive pulmonary disease (COPD).Methods The concentrations of α-granular membrane protein and D-double dime at the acute and remission stages in 30 cases of COPD through the enzyme linked immune double antibody method and were compared with those in 22 healthy cases.Results The concentrations were much higher than those in the contrast group(P<0.01), as well as at the remission stage(P<0.05).Conclusion Platelet and coagulation activations contribute to the development of COPD.