肝病患者血清维生素E水平检测及临床意义

Detection of vitamin E levels in sera of patients with liver diseases and its clinical signficance.

目的:分析维生素E水平在肝细胞病变过程中的改变。方法:采集急、慢性肝炎、肝硬变、肝癌患者及正常健康者血清,以化学法分析血清维生素E含量并进行比较。结果:在肝细胞病变过程中,血清中维生素E含量明显改变;在急慢性肝炎、肝硬变、肝癌患者血清中维生素E含量均显著低于正常对照(P<0.05),而肝癌组血清维生素E水平显著低于急慢性肝炎和肝硬变组(P<0.001)。结论:肝细胞病变过程中血清维生素E水平改变可能与体内氧化或抗氧化系统失衡有关。

Objective: To explore the variation of serum vitamin E(Vit E) in patients with different liver diseases. Methods: The concentrations of serum Vit E were detected in patients with acute hepatitis(AH),chronic hepatitis(CH), liver cirrhosis(LC), hepatocelluar carcinoma(HCC) and normal subjects as control, their results were compared between each other. Results:The serum Vit E concentrations were increased in patients with liver diseases. The serum Vit E concentrations of AH,CH, LC and HCC were significantly lower(P<0.05) than that of control group.The serum Vit E levels in sera of hepatoma patients were significantly lower(P<0. 001) than those in AH, CH and LC, respectively.Conclusion:The present data suggest the level of serum Vit E may be correlated with the imbalance of oxidation/ anti - oxidation system in patients with liver diseases.