果糖注射液与葡萄糖注射液随机盲法平行对照的临床研究

A random blind parallel control study of fructose and glucose injection.

目的:观察5％果糖注射液对需胃肠外补充能量的病人的临床疗效,以评价果糖注射液的有效性及安全性。方法:随机盲法选取125例病人,分5％果糖组及5％葡萄糖组,观察两组病人在输液前、输液后及输液后2小时血糖水平及治疗前、停药后血常规、肝肾功、血尿酸的变化。结果:果糖组与葡萄糖组临床有效率均为100％,果糖组仅第2日输液后的血糖水平明显高于输液前。葡萄糖组输液后血糖水平均明显高于输液前。果糖组和葡萄糖组输液后2小时的血糖水平均恢复至输液前水平。果糖组血糖波动小于葡萄糖组。结论:果糖注射液安全有效,对病人血糖影响小于葡萄糖。

Objective:To evaluate the effectiveness and reliability of frunctose injection, we observed the clinical efficacy of 5% fructose injection in the patients who need to supply energy. Methods: 125 patients were randomly assigned into fructose and glucose groups. They received fructose or glucose injection distinguishably, then were observed the level of blood sugar and the change of blood routine, function of liver and kidney and blood uric acid before and after treatment. Resul ts: The clinical effective rate was 100% in both groups, The blood sugar of fructose group after infusion was higher than before infusion on second day.The blood sugar of glucose group after infusion was all higher than before infusion. Two group's blood sugar after 2 hours infusion returned to before infusion. Fructose group had smaller fluctuation to blood sugar than glucose group. Conclusion:Fructose injection is efficient and safety,had smller influence to blood sugar than glucose injection.