摘要
目的 :按实例建立局部植入给药的局部药物浓度时空方程。方法 :以加权平均及多元分析的方法 ,分别求算局部药物浓度的空间和时间分布函数 (药物浓度经时方程 )。结果 :四维时空的局部植入给药的局部药物浓度时空方程为 :C(t ,X ,Y ,Z) =(B0 +B4r3 +B5r2 )× (A1e-Kat+A2 e-Ket+A3 e-Krt) =(1.343+0 .0 18r3 - 0 .6 2 5r2 )×(2 0 6 .0 8e-0 .0 0 3 8t- 15 .4 8e-0 .2 184t- 190 .6 0e-0 .0 444t) ,r =(X2 +Y2 +Z2 ) 1/ 2 。结论 :经实例演算 ,时空方程的理论基本合理 ,有较好科研价值 ,有助于揭示局部给药的药代动力学规律。
Objective:To set up the local plasma drug concentration-space-time equation of the local embedding administration.Methods:The space position function and time function were set up using of local drug concentration,as well as local drug concentration-space-time equation were set up using mathematical methods of weighted mean and multivariate analysis.Results:The local drug concentration equation in the fourth dimension according to animal experiments was as below:C(t,X,Y,Z)=(B 0+B 4r3+ B 5r2)×(A 1e -Kat+A 2e -Ket+A 3e -Krt)=(1.343+0.018r3-0.625r2)×(206.08e -0.0038t- 15.48e -0.2184t- 190.60e -0.0444t),r=(X2+Y2+Z2) 1/2.Conclusion:The theory of function was rational via deduction of animal experiments and was value of scientific research,it would be redounded to reveal the pharmacokinetics rule of local administration.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2003年第5期363-367,共5页
Chinese Journal of New Drugs
基金
国家科学技术部基础研究快速反应支持项目 (国科基字 2 0 0 1-5 1#)
关键词
时空方程
时间分布函数
空间分布函数
加权平均
多元回归
局部药物浓度
space-time equation
plasma concentration-time equation (function)
plasma concentration-space position equation (function)
weighted mean
multivariate analysis
