阿罗洛尔治疗老年原发性高血压的临床研究

The clinical efficacy of arotinolol in senile patients with essential hypertension

目的 :观察小剂量阿罗洛尔治疗老年原发性高血压的疗效。方法 :6 5岁以上原发性高血压患者 4 1例 ,采用自身前后对照方法予以阿罗洛尔 5mg ,bid ,治疗 8周 ,其中 12例进行动态血压监测比较。 结果 :通过阿罗洛尔治疗 8周 ,收缩压从 (2 1.71± 2 .2 0 )kPa下降为 (18.5 4± 1.80 )kPa(P <0 .0 1) ,舒张压从 (12 .86± 1.6 7)kPa下降为 (11.2 7± 1.4 2 )kPa(P <0 .0 1) ;12例动态血压监测结果显示 ,小剂量阿罗洛尔在白昼和夜晚均能平稳降压 ,且两者差异无显著性。降压疗效 :显效率 5 8.5 % (2 4 / 4 1) ,有效率 31.7% (13/ 4 1) ,总有效率 90 .2 %。不良反应轻微 ,心动过缓无 1例低于 5 0次·min-1。结论 :小剂量阿罗洛尔能降低原发性高血压患者的收缩压和舒张压 ,疗效显著且降压作用平稳 ,具有良好的耐受性。

Objective:To observe the efficacy of small dose arotinolol in treatment of senile patients with essential hypertension.Methods:The self-controlled study was conducted in 41 patients (>65 years old) with hypertension.They were treated with arotinolol 5mg twice daily for 8 weeks,and the ambulatory BP was monitored in 12 of them.Results:After 8 weeks treatment,the mean systolic pressure decreased from (21.71±2.20)kPa to (18.54±1.80)kPa(P<0.01) and the mean diastolic pressure decreased from (12.86±1.67)kPa to (11.27±1.42)kPa(P<0.01)?The result of ambulatory BP monitoring in 12 patients shows that a steady BP can be maintained without fluctuation throughout 24h by small dose arotinolol.The effctive rate and total effective rate of the study are 31.7%(13/41) and 90.2% respectively with mild ADRs.Conclusion:Small dose of arotinolol is effective for essential hyertension and a steady BP can be maintained by it throughout 24h without fluctuation.