不同盐敏感性者心理应激时血浆血管紧张素Ⅱ、醛固酮和心钠素浓度的变化

The Effect of Laboratory Mental Stress on Plasma Levels of Angiotensin II,Aldosterone and Atrial Natriuretic Peptide in Different Salt-Sensitivity Individuals

目的 :探讨盐敏感者心理应激时血浆血管紧张素Ⅱ (AngⅡ )、醛固酮 (ALD)和心钠素(ANP)浓度的变化。方法 :以 48名健康的男大学生为研究对象 ,用口服盐水法将其分为盐敏感组与盐不敏感组 ,用速算比赛使其产生心理应激 ,比较两组人群心理应激前后血压、血浆AngⅡ、ALD与ANP的浓度。结果 :48名血压正常的大学生中 ,盐敏感者 14人 ,非盐敏感者 3 4人 ;两组人群心理应激后血压、血浆AngⅡ与ALD浓度均较应激前增加 (P <0 0 5 ) ,且盐敏感者上述三项指标的增幅较非盐敏感者大 (P <0 0 5 ) ,但两组人群应激前后的血浆ANP浓度无明显改变 (P >0 0 5 )。结论 :盐敏感者心理应激所致的血压、血浆AngⅡ与ALD浓度的增加幅度较非盐敏感组大 ;盐敏感与精神紧张在高血压病的发病过程中可能存在交互作用。

Objective:To study the influence of laboratory mental stress on plasma levels of angiotensin II (Ang II), aldosterone(ALD)and atrial natriuretic peptide (ANP) in individuals with different salt sensitivity Method:48 healthy male undergraduates were divided into salt sensitive group (SS group, n=14) and non-salt-sensitive group (NSS group, n=34) Their blood pressure, plasma levels of Ang II, ALD and ANP were measured before and after mental arithemtic test Result:Blood pressure, plasma levels of Ang II and ALD increased significantly in both groups, with SS group having greater increase Plasma level of ANP had no change after the test Conclusion:Laboratory mental stress increases the plasma levels of Ang II and ALD in male students Salt-sensitivity can magnify this effect