粘着斑蛋白α-catenin在大鼠心脏中的表达

Expression of α-catenin in rat heart

目的 探讨粘着斑蛋白α catenin在大鼠心脏中的表达分布方式以及心肌细胞发育过程中增龄变化规律。方法 应用S -P免疫组化方法分别对幼年、青年、中年和老年大鼠的心肌细胞粘着斑蛋白α catenin的表达进行观测。结果 细胞粘着斑蛋白α catenin在大鼠的心房、心室、乳头肌、室间隔等处均有表达。幼年时期α catenin的免疫标记颗粒大部分集中在心肌细胞末端的闰盘处 ,少量分散地分布于细胞表面和胞浆中 ;青年、中年和老年大鼠α catenin的免疫标记典型分布在心肌细胞末端的闰盘处。结论 在大鼠心肌发育过程中 ,α catenin的表达分布存在增龄变化 ;粘着斑蛋白α

Objective To investigate the spatio-temporal pattern α-catenin in rat heart and age-related changes of α-catenin expression during development of rat myocytes. Methods Immunohistochemical method was used to monitor the myocardial α-catenin distribution in infant, young ,adult and old rat respectively.Results The expression of α-catenin was prescented in myocytes of atrium and ventricular and interventricular septum. In infant rat,immunolabeling granus of α-catenin were distributed in the end intercalated disk, a little of α-catenin distributed on the cardiomyocyte surface and cytoplasm. In rat heart from young to an old age ,the typical α-catenin granus was distributed in transversely orientated intercalated disk.Conclusions The progressive age-related changes exists in α-catenin expression and the changing pattern of α-catenin is closely related to the development of the intercalated disk in rat myocardium.