超氧化物歧化酶在卵巢癌诊断及监测中的意义

Assessment of Superoxide Dismutase in Diagnosis and Monitoring of Ovarian Carcinoma

目的 :评价超氧化物歧化酶 (SOD)诊断及监测卵巢癌的临床价值。方法 :测定 2 6例卵巢癌、32例卵巢良性病变及 16例正常妇女血清总超氧化物歧化酶 (T SOD)、锰超氧化物歧化酶 (Mn SOD)及CA12 5,并进行分析。结果 :卵巢癌Mn SOD较卵巢良性病变及正常妇女明显降低 (P <0 0 5 )。Mn SOD诊断卵巢癌的灵敏度为 72 % ,特异度为 83.33% ,Mn SOD与CA12 5结合诊断卵巢癌的灵敏度为 92 % ,特异性为 10 0 %。动态观察 14例术后患者 6～ 12个月 ,结果Mn SOD及CA12 5值与病情转归一致。结论 :Mn SOD与CA12 5在卵巢癌诊断和监测中有较好的一致性。

Objective:To evaluate the superoxide dismutase(SOD)in diagnosis and monitoring the course of patients with ovarian carcinoma.Methods:Serum level of total SOD Manganese Superoxide dismutase(Mn-SOD) and Cancer antigen 125(CA 125 )were measured in 26 patients with ovarian carcinoma,32 with benign ovarian tumor and 16 hormal women as controls.Results:The level of Mn-SOD was significantly lower than that of the benign ovarian tumor and the control group( P <0.05).The sensitivity and specificity in diagnosis of ovarian cancer were 72% and 83.33% respectively for Mn-SOD alone(<38 μU/ml),it can be reached 92% and 100% respectively when combining Mn-SOD with CA 125 .Conclusions:Mn-SOD is coincident with CA 125 in diagnosis and monitoring the course of patients with ovarian carcinoma.