38例药源性恶性综合征的处理对策及再用药分析

The Management and Analysis of Resusing Drugs in 38 Patients with Neuroleptic Malignant Syndrome.

目的 探讨药源性恶性综合征处理对象、转归以及再次服用抗精神病药物的安全性。方法 收集1984～2001年期间38例精神药物引起的恶性综合征,分析了用药情况、临床症状特点、处理措施以及再次服用抗精神病药物的情况。结果32例恶性综合征患者经抢救症状缓解,6例死亡。其中20例患者再次服用抗精神病药物治疗后精神疾病痊愈。结论 对有恶性综合征病史的病人,最安全的用药是在症状缓解2周后选用低效价、小剂量的抗精神药物如氯氮平、舒必利以及甲硫达嗪。

Objective To explore the management couatermeasure,prognosis and the safety of reusing drugs in patients with neuroleptic malignant syndrome(NMS) caused by drugs. Method The circumstance of reusing drugs clinical symptoms,management and reusing antipsychotic drugs were analyzed in the 38 patients with NMS during 1984 - 2001. Results Symptoms of 32 patients were relieved by reusing antipsychotic,20 patients healed and 6 patients died. Conclusion To the patients with NMS,it is the safest to administer low-titer and small dose antipsychotic drugs.