不同抗凝治疗预防紫癜性肾炎发生的临床观察

Preventive effect of differents anticoagulents on the development of nephropathy in henoch-schoenlein purpura

目的:探讨不同抗凝治疗预防紫癫性肾炎的临床有效性和安全性。方法:120例过敏性紫癫患儿随机分为A组(基础治疗组)、B组(双嘧达莫+丹参组)、C组(肝素组),三组患儿每1-2周观察尿常规至治疗后6个月。结果:肾炎发生率分别为A组51.2％(22/43)、B组28.9％(13/45例)、C组6.25％(2/32例)。C组肾炎发生率明显低于B组和A组(P<0.05和P<0.01),B组肾炎发生率明显低于A组(P<0.05),所有患儿在治疗期间未见出血等副作用。结论:抗凝治疗能预防紫癫性肾炎的发生,肝素组疗效优于双嘧达莫和丹参组。

Objective: To evaluate the preventive value of differents anticoagulants on the development of nephropathy in patients with heno-schoenlein purpura (HSP). Methods: One-hundred and twenty patients with HSP were enrolled in the study and divided randomly into three groups: control group (A), persantin plus red sage root group (B), heparin group (C), and observed pallets' routine uronoscopies for moe than six months. Results: The incidence of nephritis was tweaty-two (51. 2% ) in A group with forty-three patients in all, thirteen (28. 9% ) in B group with forty-five patients and two (6. 25% ) in C group with thirty-two patients, respectively. The incidence of nephritis in C group was significantsly lower than that in group A and B ( P < 0. 01, P < 0. 05), and the incidence in group B was significantly lower than that in group A(P<0. 05) . No severe side effects, such as bleeding, were observed during the process of treatment. Conclusion: Anticoagulants could significantly reduce the incidence of HSPN. Heparin, which was safe and tolerant for patients, was more effective than persantion plus red sage root.