儿童新隐球菌脑膜炎15例临床分析

Clinical analyses of 15 cases pediatric cryptococcal meningitis

目的:探讨儿童新隐球茵脑膜炎的诊治。方法:对15例儿童新隐球菌脑膜炎临床资料进行回顾性分析。结果:发热、呕吐、头痛、抽搐、脑膜刺激征阳性是儿童新隐球茵脑膜炎的主要症状。与其它颅内感染在临床上无显著差异。结论:儿童新隐球茵脑膜炎确诊要靠病原学检查,脑脊液墨汁染色法鉴别新隐球茵甚为重要。AMB联合FLU是治疗儿童新隐球茵脑膜炎的较好方法。

Objective: To discuss the diagnosis and treatment of pediatric cryptococcal meningius. Methods: Clinical data of 15 cases of pediatric cryptococcal meningitis was retropectively reviewed. Rusult: The principal symptoms of pediatric cryptococcal meningitis are fever, vomiting, headche, tic and meningismus postive, Compare with other intracranial infection, no signficance difference in clinic was found. Conclusion: Pediatric cryptococcal meningitis was to be confirmed with pathogen examination, esp. with the method of India ink staining wich could find cryptococcus neoformans. Amphotericin B (AMB) combined with fluroconazole (FLU) is effective in treating pediatric cryptococcal meningitis.