不同血液净化疗法对尿毒症患者血清β_2微球蛋白的影响

Clearance effect of different blood purification on serum β_2-microglobulin in uraemia patients.

目的 探讨维持血液透析 (CHD)、维持血液透析加间断性血液滤过 (HF)和持续性不卧床腹膜透析 (CAPD)对 β2 微蛋白 (β2 M)的清除作用。方法 5 3例尿毒症患者随机分为 3组 :CHD组 2 5例、CHD加间断性HF组 13例、CAPD组 15例 ,观察尿毒症患者透析前后β2 M水平的变化。结果 CHD组透析后 β2 M水平较透前增加 (16 1.4 0± 72 .11) % ;CAPD组透析后β2 M水平较透前下降 (32 .30± 12 .78) % ,CHD加间断性HF组滤过后β2 M水平较滤过前下降 (4 9.98± 17.5 3) % ,CHD加间断性HF组和CAPD组间与CHD组比较 ,血清β2 M下降率差异有显著性意义 (P <0 .0 5 )。结论 CAPD、HF对 β2 M的清除明显优于CHD。

Objective To study the clearance effect of continuous hemodialysis(CHD), CHD combination of hemofiltration(HF) and continuous ambulatory peritoneal dialysis(CAPD) on serum β 2 microglobulin.Methods 53 patients with uremia were randomly divided into CHD group(25 cases), CHD combination of HF group (13 cases ) and CAPD group (15 cases) for observing the change of serum β 2 microglobulin after dialysis.Results A great difference was observed in the level of serum β 2 microglobulin between before and after dialysis in every group. In CHD group, the level of serum β 2 microglobulin increased after hemodialysis, with the change rate of 161.40±72.11%. However, the level was lower after CAPD than that before dialysis by rate of 32.30±12.78%, and a great decreased rate was observed in CHD combination of HF group after therapy by 49.98±17.53%. Decreasing rate of serum β 2 microglobulin have significant difference ,comparing the CHD combination of HF group and CAPD group with CHD group( P <0.05).Conclusion There is a great of better clearance effect of CHD combination of HF and CAPD on serum β 2 microglobulin than that of CHD.