甘油三酯与冠心病的关系研究

The relationship between triglyceride and CAD

目的 研究并验证甘油三酯 (TG)与冠状动脉损害程度的关系以及对冠心病流行病学意义。方法 选取1 996年以来我院所做冠脉造影且资料齐全的病例共 631例 ,统计分析TG与冠心病的相关性以及与其他危险因素的关系。结果 冠脉造影阳性组空腹TG为 2 1 2± 1 .2 6(n =40 7) ,阴性组为 1 .54± 0 .33(n =2 2 4 ) ,P <0 0 5 ;两组的总胆固醇(TC)分别为 5 .37± 0 .646和 4.67± 0 .642 ,P <0 0 5 ;两组的低密度脂蛋白胆固醇 (LDL C)分别为 2 87± 0 .65和 2 .32± 0 .83,P <0 0 5 ;TC与TG、LDL C之间作相关性检验 ,均显示有显著的相关性 ,P <0 0 5;分别以血糖、血压水平以及性别对上述结果进行校正 ,未得出相反结果。

Objective The role of triglyceride(TG) as a independent risk factor for coronory artery disases has long been controversed.In present study,we examinod the independent correlation and epidemiological implication between TG and CAD.Methods We enrollod 631 patients with complete records of coronary angiography done in our hospital since 1996. All data includeing TG and other risk factors had been statistically treated. Results All cases were divided into two groups:positive and negative groups,according to the result of angiography.TG had statistically significant difference between two groups:2.12±1.26( n =407)in positive group vs 1.54±0.33( n =224)in negative group, P < 0.05 ;at the same time,total cholesterin(TC) and low density lipoprotein cholesterin(LDL C)had statistically significant result,5.37±0.646( n =407)in positive group vs 4.67±0.642( n =224)in negative group, P <0.05,and 2.87±0.65( n =407) in positive group vs 2.23±0.83( n =224)in negative group , P <0.05,respectively.L line regressive analysis,showed a direct correlation between TG,TC and LDL C,and each correlative efficient had statistically significant difference, when tested with the rank result of angiography.And there was no contradictional result when adjusted by blood pressure,fasting blood glucose and gender.Conclusion TG is a independent risk factor for CAD,and physicians should pay more attention to it.