正常儿童红细胞免疫功能的测定

Determination of erythrocyte immune function in normal children

目的 探讨红细胞免疫功能在小儿各年龄组的变化。方法 0～ 2 8d,～ 3岁 ,～ 7岁 ,～ 14岁各年龄组选择 3 0名健康儿童 ,采用郭氏法 ,用微量指血检测红细胞 C3 b补体受体粘附率 ( RC3 b R) ,红细胞免疫复合物粘附率 ( RICR) ,肿瘤红细胞粘附率 ( TRR) ,同时选择 3 0名健康成人为对照。结果 儿童期各年龄组 RC3 b R、RICR、TRR与成人比较 ,儿童期男女之间比较 ,新生儿与成人比较 ,P均 >0 .0 5。结论 红细胞免疫功能的各项指标 :RC3 b R、RICR、TRR从新生儿一出生已达成人水平 ,儿童各年龄段无明显变化 。

Objective To explore the changes of erythrocyte immune function in the normal different aged children.Methods One hundred and twenty healthy children aged from 0 to 14 years were selected at random and divided into four groups (0～28 d,～3 years,～7 years,and～14 years).Their finger tittle blood samples were collected and the adherence rate of complement 3b-receptor on the surface of red blood cell (RC3bR),the immune complex adherence rate of RBC (RICR) and the adherece rate of tumor cell and RBC (TRR) were checked with Guo′s method.At the same time,30 healthy adults were chosen as control group.The materials obtained in laboratory were shown by ±s,and t-test was performed according to statistic method.Results There were no differences in RC3bR,RICR and TRR between the adult and different aged groups (P>0.05),no difference between boys and girls in children (P>0.05),and there was a same result in newborn and adult.Conclusion The indexes of the newborn on erythrocyte immune function,for example,RC3bR,RICR and TRR,have come to the level of adult′s ones when he or she was newly born;there are no marked differences among various-aged groups;the indexes can be used as an item of routine examination for infants and children to prevent the immune complex disease.