温脾汤附子先煎、大黄后下的研究

Study on first decocted Radix Aconiti Preparata and later decocted Radix et Rhizomea Rhei in Wenpi Decoction

目的 探讨温脾汤先煎后下的条件。方法 采用 HPCE法测定了温脾汤中乌头碱及大黄游离蒽醌的含量。结果 附子先煎 30 min,乌头碱的含量能达到安全限量 ;大黄先浸泡 30 min并于汤剂煎好前 10 min加入 ,大黄游离蒽醌的含量最高。结论 温脾汤中附子应先煎 ,而大黄宜后下。

Object To study the condition of Wenpi Decoction (WPD) with being decocted first and later added medicinal materials. Methods Contents of aconitine and free anthraquinone in WPD were determined by HPCE. Results Aconitine could reach the safe limit after Radix Aconiti Preparata being decocted 30 min first and the content of free anthraquinone was the highest after Radix et Rhizomea Rhei being decocted 10 min later. Conclusion Radix Aconiti Preparata should be decocted first and Radix et Rhizomea Rhei should be decocted later in WPD.