慢性阻塞性肺疾病患者血浆一氧化氮与脂蛋白(a)的变化

A STUDY ON NITRIC OXIDE AND LIPOPROTEIN(A) IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

目的 观察慢性阻塞性肺疾病患者不同时期血浆中一氧化氮脂蛋白 (a)的变化及相互关系。方法 检测 4 0例慢性阻塞性肺疾病患者急性发作期和缓解期的一氧化氮和Lp(a)水平 ,并设对照组。结果 慢性阻塞性肺疾病患者急性发作期一氧化氮明显低于缓解期 (P <0 0 1 ) ,缓解期一氧化氮明显低于正常对照组 (P <0 0 5 ) ;脂蛋白 (a)水平 (中位数 )为 30 1 4 6mg/L较对照组 1 5 5 6 1mg/L显著升高 (P <0 0 1 )。结论 低水平的一氧化氮和高水平的脂蛋白 (a)是慢性阻塞性肺疾病的重要致病因素 。

Objective To study the change and relationship of nitric oxide and lipoprotein(a)[Lp(a)] in chronic obstructive pulmonary disease (COPD).Methods The level of nitric oxide and Lp(a) were detected in 40 COPD and 40 normal group.Results The nitric oxide level in patients with acute exacerbations of COPD was significantly lower than that in control group(P<0 01);The nitric oxide level in patients with stable COPD was significantly lower than that in control group(P<0 05);The Lp(a) level in patients with acute exacerbations of COPD(301 46mg/L) was elevated than that in control group(155 61mg/L,P<0 01).There was negtive correlation between Lp(a) level and nitric oxide level.Conclusion The high level Lp(a) and the low level of nitric oxide may play an important role in COPD,Lp(a) level was closely associated with nitric oxide level.