X染色体异常对人类卵巢发育及功能影响的研究

Influence of chromosome X abnormity on development and function of human ovary

犤目的犦探讨X染色体对人类卵巢发育及功能影响的遗传学效应。犤方法犦对28例X染色体数目或结构异常的原发闭经、继发闭经和不规则闭经患者进行分析,同时进行性激素水平检测。犤结果犦X染色体数目异常17例;结构畸变11例。45,X0患者,促卵泡激素FSH和黄体生成素LH高于正常值,t值分别为19.565、19.901,P值均为0.000;且高于其他数目异常个体(FSH)、(LH)水平,t值分别为4.531、3.478,P值为0.012、0.013。犤结论犦X染色体数目异常或结构畸变,是造成卵巢发育和功能障碍的主要因素。

To probe into the genetic effect of chromosome X on the development and function of human o-vary.Twenty-eight patients with primary or secondary or irregular amenorrhea due to numerical or struc-tural abnormity of chromosome were analyzed.Their sex hormone was detected simultaneously.Seventeen cas-es belong to numerical abnormity and11cases to structural abnormity.FSH and LH in cases with45,X0were higher than in healthy person[t=19.565(FSH),t=19.091(LH),P=0.000(FSH,LH)].They also higher than in other patients with numerical abnormity[t=4.531,P=0.012(FSH);t=3.478,P=0.013(LH)].[Conclusion]Numerical or structural abnormity of chromosome X are the main causes of disturbance of ovary development and function.