门冬氨酸钾镁治疗急性心肌梗死对QT离散度的影响

Effect of potassium-magnesium aspartate on corrected QT dispersion in patients with acute myocardial infarction

目的 :评估门冬氨酸钾镁治疗急性心肌梗死对QT离散度的影响。方法 :采用随机、单盲、对照的方法将44例急性心肌梗死患者在常规治疗的基础上分为两组。治疗组 (n =2 1 )给予静脉门冬氨酸钾镁治疗 ,对照组(n=2 3 )不用门冬氨酸钾镁治疗。取入院时、入院后 2 4h及 1周的心电图 ,测量QT离散度 ,观察急性心肌梗死后心律失常的发生率。结果 :治疗组与对照组QT离散度在入院后 2 4h分别为 61 .62±7.3 5ms和 71 .0 6±1 4.0 1ms(P <0 .0 5 ) ,1周时分别为 5 3 .0 7± 5 .64ms和 66.0 0± 1 0 .5 1ms(P <0 .0 5 )。治疗组与对照组住院期间室性心律失常的发生率分别为 2 3 .8%和 5 6.5 % (P <0 .0 5 )。结论 :门冬氨酸钾镁治疗急性心肌梗死可以减少QT离散度和室性心律失常的发生率。

Objective:To evaluate the effect of potassium magnesium aspartate on corrected QT dispersion (QTcd) in patients with acute myocardial infarction. Methods:Forty four patients with acute myocardial infarction were prospectively and randomly assigned in a one blind fashion to receive intravenous potassium magnesium aspartate over five days (magnesium group, n =21) or placebo (control group, n =23). QTcd were measured with 12 ECG on arrival at hospital (baseline), 24h and 1 week later. The ventricular arrhythmia after acute myocardial infarction was recorded. Results:QTcd in two groups was 61.62±7.35ms and 71.06±14.01ms at 24h ( P <0.05); 53.07±5.64ms and 66.00±10.51ms 1 week later ( P <0.05), separately. The incidence of ventricular arrhythmia in two groups was 23.8% and 56.5% ( P <0.05), separately. Conclusion: Early administration of potassium magnesium aspartate might decrease QTcd and incidence of ventricular arrhythmias in acute myocardial infarction.