米非司酮配伍利凡诺在中孕引产中的效果观察

Effect of Antiprogestin and Rivanolum on Termination of Second Trimester Pregnancy

目的 比较单用利凡诺与米非司酮配伍利凡诺在中孕引产中的疗效。方法 选择 5 5例孕 1 6～ 2 0周因各种原因需要终止妊娠者 ,随机分成两组 ,米非司酮配伍利凡诺作为实验组 ,予米非司酮 2 0 0mg顿服 ,1 2小时后予利凡诺1 0 0mg ;对照组单用利凡诺 1 0 0mg。观察两组分娩时间、产时出血量和胎盘残留情况。结果 (1 )从最后一次给药开始到胎儿娩出时间 ,实验组明显短于对照组 (P <0 .0 5 )。 (2 )米非司酮配伍利凡诺能明显减少胎盘残留 ,优于对照组 (P <0 .0 5 )。 (3)米非司酮配伍利凡诺 ,能快速关闭血窦 ,减少出血量 ,与对照组相比差别有显著性 (P <0 .0 5 )。结论 米非司酮配伍利凡诺在中孕引产中能明显缩短胎儿娩出的时间 。

Objective To evaluate the effect of Antiprogestin and Rivanolum on termination of second trimester pregnancy. Methods 55 women needing terminating pregnancy with 16～20 weeks gestation were derived into 2 groups randomly. Group A was given Antiprogestin 200 mg firstly, and followed by 1% Rivanolum 100 mg 12 hours late.Group B was given 1% Rivanolum 100 mg only. The labor time, the amout of lost blood and the rate of remaining placenta were observered respectively. Results (1) The time from the last medication given to the end of pregnancy in group A was shorter than that in group B, P<0.05; (2) Antiprogestin and Rivanolum could obviously reduced the rate of remaining placenta and close rapidly the sinus and reduce the losing blood during labor. Conclusion Antiprogestin and Rivanolum could short the labor time, reduce the losing blood and the rate of remaining placenta in termination of second trimester pregnancy.