步行锻炼对慢性乙型肝炎患者肝功能和生活质量的影响

Effect of walking exercise on liver function and life quality in patients with chronic hepatitis B

目的为验证运动疗法促进肝功能恢复的假设,探讨步行锻炼对慢性乙型肝炎患者肝功能和生活质量的影响。方法73例慢性乙型肝炎患者每天进行30min以上的匀速步行锻炼,持续2个月,同时给予药物治疗。68例对照组仅进行药物治疗。于开始步行锻炼和药物治疗前以及治疗结束后1周内,分别检测HBVM(HbsAg、抗-HBs、HbcAg、抗-Hbe及抗-HBc)、HBVDNA、肝、肾功能、血糖和血脂、血常规。采用健康调查简易量表(medicaloutcomesstudy,SF-36)评定生活质量指数(QLI)。结果两组患者的多数肝功能指标均较治疗前有显著改善(χ2=2.784,P<0.05),但组间差异不明显(χ2=1.956～2.312,P>0.05)。治疗后步行锻炼组的SF-36生活质量问卷得分不仅明显高于治疗前(t=2.1～2.8,P<0.01～0.05),同时也优于对照组(t=2.1～2.4,P<0.05)。两组的完全反应、部分反应和无反应例数分布接近,无明显差异(χ2=2.784,P>0.05)。结论短期步行锻炼能显著改善慢性乙型肝炎患者的生活质量,但对肝功能指标影响不大。

Aim To discuss the effect of walking exercise on liver function and life quality of patients with chronic hepatitis B.Methods Exercise group:73 patients with chronic hepatitis B, 41 males and 32 females, a mean age of (14±8) years old,were chosen to walk 30 minutes every day and take medicine in 2 months.Control group:68 cases,42 males,26 females,with a mean age of (40±10) years old,were chosen only to take medicine.HBvM,HBvDNA,blood sugar,liver,and renal function were measured before and 1week after treatment.Medical outcomes study (SF 36) was conducted to examine the quality of life(QLI) in two groups.Results Most indices of liver function significantly improved after treatment in two groups (χ2=2.784, P< 0.05),however,there were no significantly difference between exercise and control group (χ2=1.956-2.312, P >0.05).The assessment of life quality (SF 36) in walking exercise group was higher than that before treatment (t=2.1-2.8,P< 0.01?0.05) as well as in control group (t=2.1-2.4,P< 0.05).There were no significant differences in the distribution of complete responsiveness,partial responsiveness and unresponsiveness between the two groups.Conclusion Short term walking exercise in patients with chronic hepatitis B only has a obvious effect on quality of life.