艾附暖宫丸治疗痛经的实验研究

Experimental Study of Aifu Nuangong Pill Treating Dysmenorrhea in Rats

目的 :探讨艾附暖宫丸治疗痛经的作用及机理。方法 :分设艾附暖宫丸小、中、大剂量治疗组 ,与吗啡组对照 ,观察对催产素致子宫剧烈收缩的痛经大鼠扭体只数、扭体发生率、抑制率以及大鼠血浆 β EP含量的影响。结果 :艾附暖宫丸小、中、大剂量组、吗啡组大鼠扭体反应只数和扭体次数明显少于病理组 (分别为P <0 .0 1) ,与吗啡组间疗效一致 (P >0 .0 5 ) ;中、大剂量组、吗啡组血浆β EP含量都有升高 ,与病理组比较有非常显著性差异(P <0 .0 1) ,吗啡组与中、大剂量组间无明显差异 (P >0 .0 5 )。结论 :艾附暖宫丸对催产素致子宫剧烈收缩的痛经大鼠有显著的镇痛作用 ,其机理与 β EP分泌增加有关。

To study the effects and its mechanism of Aifu Nnangong pill on dysmenorrhea. Methods: Treatment groups with various doses (including low, middle and high doses) Aifu Nuangong pill was given by stomach, control group with morphine. The effects of Aifu Nuangong pill on models of rats by means of oxytocin causing rats myometrium to shrink severely with wring times, the incidence of contortion and restrain, the content β EP in rat were observed. Results: The various doses Aifu Nuangong pill could obviously restrain wring times of oxytocin incenting on rats ( P <0.01) and obviously increase the content of β EP in blood plasma of experimental rats, contrasting with group of pathology ( P< 0.01). Conclusion: Aifu Nuangong pill can ease pain caused by oxytocin and this effect mechanism is correlative with increasing β EP in blood plasma.