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导致透析患者心脏病变原因的新认识 被引量：2

The current evaluation of cause of cardiac disease in dialysis patients
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摘要 心血管疾病(CVD)是慢性维持性血液透析患者的主要并发症.当患者进入终末期肾肾病(ESRD)时,有相当多的患者出现心血管疾病的症状.美国肾脏病资料库显示,在3399例开始血液透析治疗的患者中40.8%已有缺血性心脏病.而在加拿大一项对822例开始血液透析患者多中心研究结果显示,心绞痛、心肌梗死、心力衰竭分别是21%、18%、35% .然而随透析治疗时间延长患病率呈升高趋势,在41个月的随访中,年新发生缺血性心脏病为3.6%,年新发生心力衰竭7.6%.ESRD住院患者中,约1/3的患者直接原因是心血管疾病,每年因心脏病及心肌梗死住院者为全部ESRD住院患者10%.心脏病也是ESRD患者死亡的首位原因,约占总死亡率的50%,美国维持性血液透析患者因心脏病死亡者为一般人群的35倍.
作者 王质刚
机构地区 首都医科大学附属北京友谊医院肾内科
出处 《中国血液净化》 2003年第6期291-294,314,共5页 Chinese Journal of Blood Purification
关键词 心脏病变 血液透析 原因 治疗 心绞痛 心肌梗死 心力衰竭
分类号 R541 [医药卫生—心血管疾病] R459.5 [医药卫生—治疗学]
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参考文献16

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同被引文献39

  • 1许扬,毕明刚,赵英凯.小鼠血管损伤后再狭窄模型的造模方法比较研究[J].中国比较医学杂志,2006,16(10):617-620. 被引量：4
  • 2Allison MA,Hsi S,Wassel CL. Calcified atherosclerosis in different vascular beds and the risk of mortality[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2012,(01):140-146.
  • 3Tang FT,Chen SR,Wu XQ. Hypercholesterolemia accelerates vascular calcification induced by excessive vitamin D via oxidative stress[J].Calcified Tissue International,2006,(05):326-339.
  • 4Gillman T,Grant RA,Hathorn M. Histochemical and chemical studies of calciferol-induced vascular injuries[J].British Journal of Experimental Pathology,1960.1-18.
  • 5Jorde R,Grimnes G. Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids[J].Progress in Lipid Research,2011,(04):303-312.
  • 6Wang H,Xia N,Yang Y. Influence of vitamin D supplementation on plasma lipid profiles:A meta-analysis of randomized controlled trials[J].LIPIDS IN HEALTH AND DISEASE,2012.42.
  • 7Pang J,Xu Q,Xu X. Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat[J].Peptides,2010,(04):630-638.
  • 8Ewence AE,Bootman M,Roderick HL. Calcium phosphate crystals induce cell death in human vascular smooth muscle cells:a potential mechanism in atherosclerotic plaque destabilization[J].Circulation Research,2008,(05):e28-e34.
  • 9Villa-Bellosta R,Millan A,Sorribas V. Role of calcium-phosphate deposition in vascular smooth muscle cell calcification[J].American Journal of Physiology-Cell Physiology,2011,(01):C210-C220.
  • 10Trion A,van der Laarse A. Vascular smooth muscle cells and calcification in atherosclerosis[J].American Heart Journal,2004,(05):808-814.

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中国血液净化
2003年 第6期

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