Cd、Cr()及复合污染对鲫鱼组织脂质过氧化的影响

Effects of Cd、Cr(Ⅵ)single and combined pollution on Lipid peroxidation in Cruciar carp

采用动物实验方法,研究了Cd、Cr( )及其复合污染对鲫鱼组织谷胱甘肽(GSH)和丙二醛(MDA)含量的影响.结果显示:低剂量的Cd对鲫鱼肝、肾GSH有明显的诱导作用,而高剂量的Cd、Cr( )则使肝、肾组织的GSH含量明显降低;肝、肾MDA含量在各处理组均高于对照,尤其是高剂量Cd、Cr( )组的肝、肾MDA水平均显著高于对照;Cd、Cr( )复合污染在GSH、MDA水平上表现为协同关系.说明Cd、Cr( )及其复合污染能引起鲫鱼组织脂质过氧化损伤.脂质过氧化作用因组织和重金属离子而异,在肝脏中,脂质过氧化作用顺序为混合重金属离子>Cr( )>Cd;在肾脏中,脂质过氧化作用顺序为Cd>混合重金属离子>Cr( ).

Using the method of animal experiment, the effects of Cd, Cr(Ⅵ) single and combined pollution on the malondialdehyde(MDA) and glutathione(GSH) content of Cracian carp(Carassius auratus) were observed. The results showed that the amount of the GSH content in liver and kidney were elevated in the low Cd concentration group(0.3 mg/L), but GSH content was significantly lower in the highdose groups of Cd,Cr (Ⅵ) (3.0 mg/L) than the control group. On the other hand, MDA levels in liver and kidney were significantly higher in the highdose group of Cd, Cr(Ⅵ) than that in control. The GSH and MDA levels of combined pollution showed synergistic effect. Comparison of extent of lipocidation between the single and combined pollutions was represented of metal mixture>Cr(Ⅵ) >Cd in the liver and of Cd>metal mixture>Cr(Ⅵ) in the kidney.