膀胱移行细胞癌中nm23和LM-R表达的临床意义

Expression and Significance of nm23,LM-R in Bladder Transition Cell Carcinoma

目的 探讨nm2 3和LM -R在膀胱移行细胞癌 (BTCC)中的表达及临床意义。方法 应用免疫组织化学S -P法研究 97例膀胱浅表性和浸润性移行细胞癌中nm2 3和LM -R的表达 ,并进行比较分析。结果 LM -R在BTCC中的总表达率为 62 3%及35 1% ,浸润性癌组nm2 3缺失同时伴LM -R高表达者显著高于浅表性癌组 (P <0 0 5 )。浅表性癌组中 75 %复发病例呈现nm2 3低表达、LM -R高表达 ,nm2 3阴性伴LM -R阳性的BTCC患者多数预后不良。结论 nm2 3的表达及LM -R的消长与BTCC的侵袭能力密切相关。联合检测肿瘤组织中nm2 3和LM

Objective To study the expression and clinical significance of nm23,LM-R in bladder transition cell carcinoma(BTCC).Methods Immunohistochemical method(S-P) was used to study the expression of nm23,LM-R in 97 cases of superficial and infiltrative BTCC.Results The expression rate of nm23,LM-R was 62.3% and 35.1% in BTCC.The patients with loss of nm23 ad higher LM-R expression in infiltrative group were more marked than in superficial group(P<0.05).75% recurrent cases of superfical group were nm23 lower and LM-R higher expression.Moreover,those patients with negative nm23 and positive LM-R expressions had bad prognosis.Conclusions The expressions of nm23 and LM-R are closely related to infiltrative ability of BTCC.The combination determination of nm23 and LM-R expressed in BTCC maybe,as indicator judging tumor early infiltration,recurrence and prognosis.