帕米膦酸二钠(博宁)联合^(153)Sm-EDTMP治疗骨转移癌疗效分析

Clinical Analyses of the Cancer with Bony Metastases Treated b Pamidronate Disodium(Bonin)in Combination with ^(153)Sm-EDTMP

目的 观察帕米膦酸二钠联合153Sm -EDTMP治疗骨转移癌的疗效、毒副作用并探讨其临床意义。方法 随机入组 71例骨转移癌患者 ,分别给予帕米膦酸二钠、153Sm -EDTMP以及帕米膦酸二钠联合153Sm -EDTMP治疗 ,对照并观察止痛效果及毒性。结果 帕米膦酸二钠、153Sm -EDTMP以及帕米膦酸二钠联合153Sm -EDTMP组的止痛有效率分别为 67%、67%和 88 5 % ,P >0 .0 5 ,提示全组差异无显著性 ,但以 χ2 分割法检验则联合组与其它单用组之间的差异有显著性 (P <0 .0 5 ) ,而毒副反应无显著性差异。结论 帕米膦酸二钠联合153Sm

Objective To observe the curative effect and toxicities and to explore the clinical significance of Pamidronate Disodium combined with 153Sm-EDTMP in treating cancer with bony metastases.Methods Seventy-one cases with bony metastases were divided into 3 groups at random:Bonin alone group, 153Sm-EDTMP alone group and group of Bonin combined with 153Sm-EDTMP,to compare and observe their effect and toxicities.Results The remission rate of bone-ache of three groups were 67%,67% and 88.5%,respectively,P>0.05,there was not marked difference,but to test with χ 2-cut-apart in the union group comparing with other groups,there was marked difference(P<0.05),but the toxicities did not have marked difference.Conclusions The bony metastases treated by Pamidronate Disodium in combination with 153Sm-EDTMP has marked effect on remitting of bone-ache.