河南新乡地区女性乳腺癌危险因素的病例对照研究

Matched Case-Control Study for Detecting Risk Factors of Breast Cancer in Women Living in Xinxiang,Henan Province

目的 调查新乡地区女性乳腺癌危险因素 ,为确定高危人群、提出预防措施提供依据。方法 我们从 1992年 4月到 1997年 4月与中国医科院肿瘤医院合作开展了《中国大样本乳腺癌病例对照调查研究》 ,这 5年中对我院就诊的经我院病理证实的乳腺癌30 0例进行病例对照研究。研究其妇科史、药物史、吸烟史及饮食史、家族史、疾病史、染发史等。结果 在单因素分析中 ,达到显著性水平的危险因素为行经期≥ 35年、服用避孕药、良性乳腺疾病史、被动吸烟及常食用蜂王浆等 ,达到显著性水平的保护因素为哺乳及常食豆类食品。条件 (logistic)多元回归分析显示 :重要的有统计学显著意义的乳腺癌危险因素是良性乳腺疾病史、被动吸烟 ;重要保护性因素是常食豆制品及哺乳。

Objective To detect the risk factors of breast cancer in women living in xinxiang in order to identify the high risk of population and to conduct proper interventions.Methods A matched case-control study was performed in 300 cases with breast cancer who live in this area.Results In the unvaried analysis from menarche to menopause period ≥35 years,taking oral contraceptives,history of benign breast diseases,passive smoking,and syrup drinking are the statistically significant risk factors of breast cancer,whereas the breast feeding and soybean food consumption are protective factors.The conditional logistic multivariate analysis revealed that the history of benign breast diseases and the passive smoking are risk factors while the soybean food products and the breast feeding are protective factors.Conclusions The risk factors of breast cancer in women living in Xinxiang are the history of benign breast diseases and passive smoking.