社区获得性金黄色葡萄球菌肺炎的临床研究

Community-acquired Staphylococcus aureus Pneumonia: A Clinical Study

目的 研究近年来社区获得性金黄色葡萄球菌肺炎的感染途径、临床特点、病原学治疗。方法 总结分析近年来收治我科的 10例金黄色葡萄球菌肺炎的临床资料。结果 10例患者中 7例因血行感染所致 ,3例为吸入性感染 ,主要表现为高热、咳嗽、咯血、呼吸困难及胸痛等 ,痰、血、骨髓共培养出 16株金黄色葡萄球菌 ,对红霉素、氨苄西林、环丙沙星、青霉素的耐药率 >5 0 % ,对苯唑西林尚敏感 ,对利福平和万古霉素均敏感。结论 社区获得性金黄色葡萄球菌肺炎以血行感染为主 ,临床表现无特殊性 ,对常用的抗菌药物如红霉素、青霉素、氨苄西林、环丙沙星的耐药率很高。

OBJECTIVE To study the infective pathway, clinical characteristic, pathogenic therapy of Staphylococcus aureus pneumonia in recent years. METHODS The clinical data of 10 subjects with S. aureus pneumonia in recent years were reviewed. RESULTS Seven subjects were caused by blood circulated infection, 3 subjects were caused by inhaled infection. The main symptoms were fever, cough, hemoptysis, dyspnea and chest pain, et al. A total of 16 S. aureus strains were obtained from blood, sputum and marrow culture, the rate of drug resistance to erythromycin, ampicillin, penicillin and ciprofloxacin was above 50%, the resistance to oxacillin was lower. All strains were sensitive to rifampin and vancomycin. CONCLUSIONS Community-acquired S. aureus pneumonia was mainly caused by blood circulated infection, with no characteristic symptoms, The resistance to erythromycin, ampicillin, penicillin and ciprofloxacin was rather high.