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白介素27 被引量:3

Interleukin 27
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摘要 白介素 2 7(IL 2 7)是一种由 p2 8和Ebi3组成异源二聚体的新型白介素 ,它能作用于活化的T细胞和NK细胞并增强IL 12介导IFN γ的产生 ,已鉴定WSX
作者 邹炜 黄仕和
出处 《生命的化学》 CAS CSCD 2003年第3期193-195,共3页 Chemistry of Life
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参考文献6

  • 1Stefan P et al. Immunity, 2002, 16(6) :779-790.
  • 2Devergne O et al. J Viol, 1996, 70(2) :1143-1153.
  • 3Devergne O et al. Am J Pathol, 2001, 159(5) :1763-1776.
  • 4Spercher CA et al. Biochem Biophy Res Commun, 1998, 246( 1 ) :82-90.
  • 5Chen Q et al. Nature, 2000, 407(6806) :916-920.
  • 6Yoshida H et al. Immunity, 2001, 15(4) :569-578.

同被引文献56

  • 1吴长有.Th17细胞:一种新的效应CD4^+T细胞亚群[J].细胞与分子免疫学杂志,2006,22(6):695-697. 被引量:36
  • 2Spercher CA, Sprecher CA, Grant FJ, et al. Cloning and characteri- zation of a novel class I cytokine receptor. Biochem Biophys Res Com- mun, 1998, 246(1):82-90.
  • 3Pflanz S, Timans JC, Cheung J, et al. IL227, a heterodimeric cy- tokine composed of Ebi3 and P28 protein, induce proliferration of na? ve CD4 + T cells. Immunity, 2(102, 16(6):779-790.
  • 4Poleganov MA, Bachmann M, Pfeilschifter J, et al. Genome-wide analysis displays marked induction of EBI3/IL227B in IL2182activated AML2derived KG1 cells: critical role of two kappa B binding sites in the hmnan EBI3 promotor. Mol Immunol, 2008, 45 (10) : 2869-2880.
  • 5Devergne O, Coulomb-L' HermineA, Capel F, et al. Expression of Epstein-Barr vires-induced gene 3, an interleukin21-p40-related molecule, throughout human pregnancy: involvement of syneytiotro- phoblasts and extravillous trophoblasts. Am J Pathol, 2001, 159(5) : 1763-1776.
  • 6Pflanz S, Hibbert L, Mattson J, et al. WSX-1 and glycoproteinl30 constitute a signal-transducing receptor for IL-27. J Irointmol, 2004, 172 ( 4 ) : 2225 -2231.
  • 7Miyazaki Y; Inoue H, Matsumura M, et al. Exacerbation of experi- mental allergic asthma by aumnented Th2 responses in WSX-1-defi- cient mice. J Immunol, 2005, 175(4) :2401-2407.
  • 8Owaki T, Asakawa M, Fukai F, et al. IL-27 induces Th1 differentia- tion via p38 MAPK/T-bet-and intercellular adhesion molecule-1/LFA- 1/ERK1/2-dependent pathways. J Immunol, 2006, 177(11): 7579- 7587.
  • 9Villarino AV, Stumhofer JS, Saris C et al. IL-27 limits IL-2 produc- tion during Thl differentiation. J Immunol, 2006, 175(1):237-247.
  • 10Morishima N, Owaki T, Asakawa M, et al. Augmentation of effector CD81 T cell generation with enhanced granzyme B expression by IL- 27. J Immunol, 2005, 175(3):1686-1693.

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