病毒性脑膜炎和病毒性脑炎患者脑脊液中一氧化氮的变化及意义

The changes of nitric oxide in cerebrospinal fluid and clinial significance in patients with viral encephalitis and virus meningitis

目的 探讨病毒性脑膜炎和病毒性脑炎 (即病脑 )患者脑脊液中一氧化氮 (NO)含量改变的临床意义。方法 应用相应试剂盒对 2 7例病脑患者和 15例非感染者 (对照组 )脑脊液中的NO进行测定。结果 病脑患者脑脊液中治疗前NO含量与治疗后及对照组比较明显增高 (P <0 .0 1)。结论 提示NO确实参与了病脑的病理过程 ,NO含量测定有助于病脑的诊断及了解病情变化。

Objectives To investigate the clinical significance of the changes of nitric oxide(NO) in cerebrospinal fluid(CSF).Methods The levels of NO in 27 patients CSF and 15 controls CSF were determined according to the instructive manual attached to respective kit.Results The NO levels of CSF were obviously increased in the patients group with viral encephalitis and virus meningitis comopared with the control group,and obvious difference between infront therapy and end therapy.Conclusions There indeed exist NO in inflammatory pathological process central nervous system.Determination of NO level of CSF would help to diagnosis the viral encephalitis and virus meningitis. [