无痴呆综合症的艾滋病患者局部脑血流的变化

Changes of regional cerebral blood flow in AIDS patients without acquired immunodeficiency syndromes dementia complex

目的 :观察无痴呆综合症的艾滋病 (AIDS)患者局部脑血流 (rCBF)的变化。方法 :对 4例无痴呆综合症的男性AIDS患者 (IV期 )进行了99mTc -双半胱乙脂 (ECD)脑血流灌注断层显像 ,并定量测定rCBF。 16例性别、年龄匹配的健康者作正常对照。结果 :4例无痴呆综合症的AIDS患者双侧额、顶、颞叶、基底节和丘脑、以及直回和桥脑rCBF明显低于正常对照组 (P <0 .0 1)。结论 :无痴呆综合症的AIDS患者存在脑皮层和皮层下rCBF减少。

AIM: To investigate the changes of regional cerebral blood flow(rCBF) in AIDS patients without acquired immunodeficiency syndrome dementia complex(ADC). METHODS: 99m Tc-ECD brain SPECT imaging was performed in 4 AIDS patients without ADC and 16 sex and age-matched normal controls. The rCBF percentage compared to the cerebellum were calculated using a semi-quantitative processing software.RESULTS: The rCBF in the right and left frontal, temporal, porietal lobe, basal ganglia and thalamus, cyrus rectus and pons were decreased significantly in AIDS patients without ADC than those of the control subjects ( P<0.01 ). CONCLUSION: There is reduced cortico-subcortical rCBF in AIDS patients without ADC.