女性经前期复发性阿弗他溃疡患者血清IL-6、IL-8、TNF-α和sICAM-1的含量变化及其意义

Alteration of serum IL-6, IL-8,TNF-α and sICAM-1 in patients with pre-menstruation recurrent aphthous ulceration

目的 :研究女性经前期复发性阿弗他溃疡 (经前期RAU)患者血清中白细胞介素 - 6 (IL - 6 )、白细胞介素 - 8(IL - 8)、肿瘤坏死因子 -α(TNF -α)和可溶性细胞间粘附分子 - 1(sICAM - 1)的变化状况 ,并探讨经前期RAU的发病机制。方法 :用酶联免疫吸附双抗体夹心法 (ELISA)检测女性经前期RAU患者外周血中IL - 6、IL - 8、TNF -α、sICAM - 1的水平 ,与正常对照组和无经前发作规律的女性RAU对照组相比。结果 :经前期RAU患者的血清IL - 6、IL - 8、TNF -α水平不仅显著高于正常对照组 (P <0 0 1) ,而且高于女性RAU对照组 (P <0 0 1)。而sICAM - 1无明显变化。女性RAU患者血清中TNF -α亦高于正常对照组 (P <0 0 5 )。结论 :经前期RAU患者体内存在IL - 6、IL - 8、TNF -α介导的免疫功能异常 ,可能对RAU局部损害起作用。

AIM: To investigate the serum levels of interleeukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-alpha(TNF-α) and soluble intercellular adhesion molecule-1 (sICAM-1)in female patients with pre-menstruation recurrent aphthous ulceration(RAU). METHODS: Serum levels of IL-6,IL-8,TNF-α and sICAM-1 in 21 pre-menstruation RAU patients were examined using ELISA technique, and compared to 10 healthy individuals and 22 the female RAU patients unrelated to menstrual cycle. RESULTS: The serum levels of IL-6,IL-8,TNF-α in patients with pre-menstruation RAU were not only significantly higher than that in the normal control group( P< 0 01),but also higher than that in the RAU patients without pre-menstruous recurrence ( P< 0 01) The level of serum TNF-α in the RAU patients without pre-menstruous recurrence was slightly higher than that in the normal control group( P< 0 05) The level of sICAM-1 had not changed. CONCLUSION: The serum levels of IL-6,IL-8 and TNF-α increase in pre-menstruation RAU patients, which might play a role in local lesion of RAU.