摘要
用乙醚麻醉大鼠,于右后足跖皮下注射福氏完全佐剂致炎.次日灌胃祛风散6.0g/kg体重,每天1次,灌胃容量5m1/只,连续7d.小鼠尾静脉注射0,5%伊文思蓝生理盐水溶液0.2m1/20g体重,腹腔注射0.6%HAc生理盐水0.2ml/20g体重,20min后处死动物,吸取腹腔液测毛细血管通透性.结果为,给药后测定,祛风散组大鼠的出血时间比风湿痹康组的延长了20.8%,凝血时间缩短了19.8%%,血沉加快了24.2%.祛风散对HAc引起的腹腔毛细血管通透性增高有明显的抑制作用,抑制率为38.5%.
The models of rheumatoid arthritis of rats were copied with Freund's completeadjuvant by hypodermic injection at right hind legs. The next day they were treated with anoral dose of Qu feng san, of 6.0 g/kg body weight once a day, for 7 days running. Then theywere injected 0. 5% Evansblue into the caudal veins of mice with a dose of 0.2 ml/20 g bodyweight and 0.6% HAc 0.2 ml/20 g body weight (pi). 20 rain after treatment, the animalswere put to death. The capillary permeability was determined with the celiac liquid. Theresult showed that in Qu feng san groups, the bleeding time was prolonged for 20. 8%, thecoagulation time reduced 19.8%, and the blood sedimentation time reduced 242%,compared with those of Feng shi bi kang group. Qu feng san had a significant inhibition effectof on the increase of capillary permeability, and the inhibitory ratio was 38. 5%.
出处
《甘肃科学学报》
2003年第2期112-115,共4页
Journal of Gansu Sciences
关键词
祛风散
类风湿关节炎
血液学
通透性
小鼠
大鼠
Qu feng san
rheumatoid arthritis
hematology
permeability
mice
rats
