基质金属蛋白酶在白血病致病和治疗研究中的进展

Role of Matrix Metalloproteinases in the Pathogenesis and Therapy of Leukemia

恶性肿瘤细胞的侵袭和转移是造成肿瘤病人死亡的重要原因 ,肿瘤细胞发生侵袭和转移与蛋白水解酶水解胞外基质密切相关 ,锌离子依赖性的基质金属蛋白酶 (matrixmetalloproteinases,MMP)中的MMP2和MMP9是参与此过程的两个关键性蛋白酶。本文就MMP结构、生理调控。

The invasion and metastasis of malignant tumor cells are important factors causing the death of cancer patients. The proteolytic activity of proteinases to most of the extracellular matrix macromolecules is closely correlated with the invasion and metastasis of malignant tumor cells . Matrix metalloproteinases(MMP) are key proteinases involved in these processes. MMP is a type of Zn 2+ depended proteinases. MMP2 and MMP9 are the unique types of proteinase that hydrolyze the bone structure of excellulary matrix (type IV collagen). So they are particularly correlated with leukemia cells infiltration and metastasis. This review aims to introduce the function of MMP and the regulation of matrix gene expression, as well as their roles in leukemia cell invasion and metastasis. A new strategy that MMP may be a therapeutic target in the treatment of leukemia is particularly introduced.