CaO—P_2O_5—SiO_2系统溶胶-凝胶玻璃的生物矿化行为

BIO-mineralization behavior of the sol-gel derived glasses in the system CaO-P2O5-SiO2 in a biological environment

利用体外实验方法(in vitro)以及XRD、SEM、FTIR、BET、ICP等手段研究了两种溶胶-凝胶生物活性玻璃的显微结构及其在模拟生理溶液(SBF)中的降解过程、表面反应产物和生物矿化机理。结果表明,两种生物活性玻璃都具有较高的生物活性,均具有由纳米尺寸颗粒相互连接而成的微孔结构和较大的比表面积,在模拟生理溶液(SBF)中浸泡后可形成表面类似天然骨中无机矿物的碳酸羟基磷灰石层(HCA),说明两者均具有较高的生物活性和生理环境相应特性。材料表面的硅酸凝胶层及其硅羟基团的形成对碳酸羟基磷灰石(HCA)微晶的成核有重要作用。

The microstructure, degradability, surface reaction products and mechanism of mineralization in SBF solution of the two sol-gel derived glasses in the system CaO-P2O5-SiO2 were investigated in vitro using XRD, SEM, FTIR, BET and ICP techniques. The results show that both sol-gel glasses have high bioactivity owing to rapid formation of hydroxy-carbonate-apatite (HCA) on the biomaterials'surface in SBF and the different behaviors of ion diffusion and bio-mineralization in SBF solution due to their different composition. The silicic acid gelatin and the formation of Si hydroxy group on the materials' surface had an important effect on nucleation and amount of HCA.