期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管内皮生长因子家族及其受体 被引量：1

The VEGF Family and VEGFR Receptor Tyrosine Kinases
下载PDF
导出
摘要 血管内皮生长因子(VEGF)家族包括VEGF-A,-B,-C,-D,-E和胎盘生长因子(PIGF),都与同型的酪氨酸激酶受体VEGFR-1(Flt1),VEGFR-2(KDR/Flk1)和/或VEGFR-3(Flt4)结合。本文综述血管内皮生长因子家族及其受体在肿瘤血管生成、淋巴管生成及肿瘤转移中的作用。 The VEGF family of angiogenic growth f ac tors includes VEGF-A,-B,-C,-D and-E as well as placenta growth factor(P IGF),which activates VEGFR-1(Flt1),VEGFR-2(KDR/Flk1)and/or VEGFR-3(Flt4)receptor tyrosine kinases.Differences in the regulation and tissue istribution of these family members suggest that they have distinct roles both during angiogenesis,lymphangio-genesis and tumor metastasis.
作者 丁明星 何卫妹 李继承
机构地区 金华职业技术学院医学院 浙江大学医学院
出处 《金华职业技术学院学报》 2003年第2期35-38,共4页 Journal of Jinhua Polytechnic
关键词 血管内皮生长因子家族 血管内皮生长因子受体 肿瘤转移 (VEGF 胎盘生长因子 酪氨酸激酶受体 VEGF family VEGFR Tumor metastasis
分类号 R730.23 [医药卫生—肿瘤]
  • 相关文献

参考文献16

  • 1Karpanen T;Egeblad M;Karkkainen M J.Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth[J],2001.
  • 2Makinen T;Jussila L;VeikkolaT.Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3[J],2001.
  • 3Stacker S A;Caesar C;Baldwin M E.VEGF-D pronotes the metastatic spread of tumour cells via the lymphatics,2001.
  • 4Skobe M;Hawighorst T;Jackson D G.Induction of tumor Lymphangiogenesis by VEGF-C promotes breast cancer metastasis[J],2001.
  • 5Niki T;Iba, S;Tokunou M.Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma,2000.
  • 6White J D;Hewett P W;Kosuge D.Vascular endothelial growth factor-D expression is an independent prognostic maker for survival in cotorectal carcinoma[J],2002(6).
  • 7Salven P;Lymboussaki A;Heikkila P.Vascular Endothelial Growth Factors VEGF-B and VEGF-C Are Expression in Human Tumors,1998(01).
  • 8Stacker SA;Stenvers K;Caeser C.Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing whith generates non-covalent homodimiers[J],1999(45).
  • 9Jeltsch M;Kaipainen A;Joukov.Hyperplasia of lymphatic vessels in VEGF-Ctransgenic mice,1997.
  • 10Soker S;Takashima S;Miao H Q.Nueropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor[J],1998(6).

二级参考文献21

  • 1吴胤瑛,李恩孝.VEGF在恶性肿瘤中的研究进展[J].现代肿瘤医学,2005,13(5). 被引量：56
  • 2Folkman J. Tumor angiogenesis:Therapentic implications[J]. New Engl J Med, 1971,285 : 1182
  • 3Folkman J.Tumor angiogenesis and tissue factor[J]. Nat Med,1996,2(2) : 167
  • 4Paavonen K, Horelli-Kuitunen N, Chilov D, et al. Novel haman vascular endothelial growth factor genes VEGF- B and VEGF - C localized to chromosomes 11q13 and 4q34, respectively[J]. Circulation, 1996,93 (6) : 1079
  • 5Oh SJ,Jeltseh MM,Birkenhager R,et al. VEGF and VEGF-C:specific induction of anglogenesis and lyraphangiogenesis in the differentiated avian chorioallantoic membrane[J]. Develop Biol,1997,188:96
  • 6Shibuya M. Role of VEGF-FLT receptor system in normal and tumor angiogenesis[ J ]. Adv Cancer Res, 1995,67 : 281
  • 7Achen MG,Jeltsch M,Kukk E,et al. Vascular endothelial growth factor D(VEGF--D) is a ligand for tyroaine kinases VEGF receptor 2(Flk- 1) and VEGF receptor 3(Fit- 4)[J]. Proc Natl Acad Sci USA, 1998,95 : 548
  • 8Velkkola T, AlitalO K. VEGFs, receptors and anglogenesis [ J ].Cancer Biology, 1999,9 : 211 - 220
  • 9Hanahan D,Folkman J. Patters and emerging mechanisms of the angiogenic seich during tumorigenesis[J]. Cell,1996,86(3) :353 - 364
  • 10Kohn S, Nagy JA, Dvorak HF, et al. Pathways of macromolecular transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood Vessels [J ]. Lab Invest, 1992,67 : 596 - 607

共引文献9

同被引文献20

  • 1吴胤瑛,李恩孝.VEGF在恶性肿瘤中的研究进展[J].现代肿瘤医学,2005,13(5). 被引量：56
  • 2Folkman J. Tumor angiogenesis:Therapentic implications[J]. New Engl J Med, 1971,285 : 1182
  • 3Folkman J.Tumor angiogenesis and tissue factor[J]. Nat Med,1996,2(2) : 167
  • 4Paavonen K, Horelli-Kuitunen N, Chilov D, et al. Novel haman vascular endothelial growth factor genes VEGF- B and VEGF - C localized to chromosomes 11q13 and 4q34, respectively[J]. Circulation, 1996,93 (6) : 1079
  • 5Oh SJ,Jeltseh MM,Birkenhager R,et al. VEGF and VEGF-C:specific induction of anglogenesis and lyraphangiogenesis in the differentiated avian chorioallantoic membrane[J]. Develop Biol,1997,188:96
  • 6Shibuya M. Role of VEGF-FLT receptor system in normal and tumor angiogenesis[ J ]. Adv Cancer Res, 1995,67 : 281
  • 7Achen MG,Jeltsch M,Kukk E,et al. Vascular endothelial growth factor D(VEGF--D) is a ligand for tyroaine kinases VEGF receptor 2(Flk- 1) and VEGF receptor 3(Fit- 4)[J]. Proc Natl Acad Sci USA, 1998,95 : 548
  • 8Velkkola T, AlitalO K. VEGFs, receptors and anglogenesis [ J ].Cancer Biology, 1999,9 : 211 - 220
  • 9Hanahan D,Folkman J. Patters and emerging mechanisms of the angiogenic seich during tumorigenesis[J]. Cell,1996,86(3) :353 - 364
  • 10Kohn S, Nagy JA, Dvorak HF, et al. Pathways of macromolecular transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood Vessels [J ]. Lab Invest, 1992,67 : 596 - 607

引证文献1

二级引证文献8

金华职业技术学院学报
2003年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部