可注射纳米磷灰石/高分子复合骨修复材料的性能

Injectable bone repairing material of nano-apatite and polymer

制备了一种新型可注射纳米磷灰石/聚酰胺66复合材料,研究了其可注射性能、在生理盐水中的凝结时间以及抗压强度。结果表明:纳米磷灰石/聚酰胺66复合材料可用针管注射,能在空气、生理盐水和血液中固化,有合理的凝结时间,高的抗压强度,可用于骨缺损的修复。在固化过程中,材料中的聚酰胺发生了物相变化,聚酰胺从结晶型相转变成无定型相,在水中固化后又转变成结晶型相;金属盐的存在破坏了聚酰胺分子间的氢键,导致了材料在固化过程中聚酰胺结构发生了变化。该材料生物相容性和生物活性好,能促进骨缺损的修复和重建。

A new type of injectable nano-apatite/polyamide66(PA) composite was prepared and investigated. The injectable material was implanted into the alveolar defects of dogs, and reconstruction of bone was evaluated by histological analysis. The results showed that injectable materials can harden not only in air and in saline, but also in blood, and have a reasonable setting time and good mechanical strength, which is very suitable for clinical application. The hardening of the bone repairing material is the process of the PA phase transition. The presence of metal salt destroyed hydrogen bonding of PA and resulted in the phase transition of PA. The injectable bone repairing material has good biocompatibility and bioactivity, and could promote the reconstruction of alveolar bone defect.